The BAU is called to investigate a series of deaths in Virginia suspected by the Center for Disease Control to be caused by bio-terrorism; Garcia visits her stepbrother to take care of a family issue.
The investigation turns to the family as the BAU and local authorities race against time to locate a young girl who has disappeared from a local shopping mall.
As a team member fights for life, the BAU continues the search for an attacker that leads the unit to believe the assailant could be someone close to the investigation.
The new sheriff in Fredericksburg, Virginia, requests the BAU's assistance in the investigation of a series of mutilation murders that appear to mimic similar crimes that had occurred over two decades earlier.
When one teenager is found murdered and her best friend is abducted in Chula Vista, California, the BAU assists local authorities in determining whether the Witness Protection Program is involved.
After the contents of a self-storage unit purchased at an auction take the BAU to Philadelphia to investigate a series of murders, the local agent becomes the center of the case. To catch the killer, the team must profile the items inside the unit.
The BAU is called to West Bune, a small town in Texas, to investigate what appears to be spree killings that involve a teenaged boy and his girlfriend.
The team members try to identify a stalker before he can attack a woman who is being stalked in Silver Spring, Maryland. Meanwhile, Hotch and Rossi are called as consultants on a possible battered woman syndrome murder case in Boston.
After a suspected serial killer wakes up from a coma, the BAU reopens the case and uses brain fingerprinting to determine if he really doesn't remember the crimes that had been committed four years earlier in Roanoke, Virginia.
The BAU faces one of its toughest cases when the team is called to New York City to determine if a series of random shootings is the work of one serial killer or a team of killers working together.
An elite team of FBI profilers analyze the country's most twisted criminal minds, anticipating their next moves before they strike again. The Behavioral Analysis Unit's most experienced agent is David Rossi, a founding member of the BAU who returns to help the team solve new cases.